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Issue 2, 2019
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Peptide ligand-mediated targeted drug delivery of nanomedicines

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Abstract

Targeted drug delivery is emerging as a promising strategy to achieve better clinical outcomes. Actively targeted drug delivery that utilizes overexpressed receptors or antigens on diseased tissues is receiving increasing scrutiny, especially due to the uncertainty of existence of the enhanced permeability and retention (EPR) effect in cancer patients. Peptide ligands are advantageous over other classes of targeting ligands due to their accessibility of high-throughput screening, ease of synthesis, high specificity and affinity, etc. In this review, we briefly summarize the resources of peptide ligands and discuss the pitfalls and perspectives of peptide ligand-mediated targeted delivery of nanomedicines.

Graphical abstract: Peptide ligand-mediated targeted drug delivery of nanomedicines

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Article information


Submitted
23 Oct 2018
Accepted
31 Dec 2018
First published
18 Jan 2019

Biomater. Sci., 2019,7, 461-471
Article type
Review Article

Peptide ligand-mediated targeted drug delivery of nanomedicines

Z. Jiang, J. Guan, J. Qian and C. Zhan, Biomater. Sci., 2019, 7, 461
DOI: 10.1039/C8BM01340C

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