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Issue 2, 2019
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Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

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Abstract

Stimuli-responsive biomaterials are useful platforms for environmentally triggered drug delivery. By varying the molecular architecture of orthogonal stimuli-labile linkages between small molecules and non-degradable materials, we demonstrate the Boolean logic-based release of model therapeutics from gels. Programmable responses are demonstrated for materials sensitive to input combinations involving enzymes, chemical reductants, and light via YES, OR, and AND logic gates.

Graphical abstract: Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

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Publication details

The article was received on 15 Oct 2018, accepted on 09 Dec 2018 and first published on 17 Dec 2018


Article type: Communication
DOI: 10.1039/C8BM01304G
Citation: Biomater. Sci., 2019,7, 542-546

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    Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

    E. R. Ruskowitz, M. P. Comerford, B. A. Badeau and C. A. DeForest, Biomater. Sci., 2019, 7, 542
    DOI: 10.1039/C8BM01304G

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