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Issue 2, 2019
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Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

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Abstract

Stimuli-responsive biomaterials are useful platforms for environmentally triggered drug delivery. By varying the molecular architecture of orthogonal stimuli-labile linkages between small molecules and non-degradable materials, we demonstrate the Boolean logic-based release of model therapeutics from gels. Programmable responses are demonstrated for materials sensitive to input combinations involving enzymes, chemical reductants, and light via YES, OR, and AND logic gates.

Graphical abstract: Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

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Supplementary files

Article information


Submitted
15 Oct 2018
Accepted
09 Dec 2018
First published
17 Dec 2018

Biomater. Sci., 2019,7, 542-546
Article type
Communication
Author version available

Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

E. R. Ruskowitz, M. P. Comerford, B. A. Badeau and C. A. DeForest, Biomater. Sci., 2019, 7, 542
DOI: 10.1039/C8BM01304G

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