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Issue 2, 2019
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Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications

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Abstract

Inorganic nanomaterials have been studied extensively in recent years because of their unique physical and chemical characteristics. Moreover, ultra-small nanoclusters (USNCs), which are less than 3 nm in size, exhibit extraordinary properties different from those of larger-sized nanoparticles. For example, ultra-small iron oxide nanoclusters (NCs) show paramagnetic properties; ultra-small noble metal NCs exhibit bright fluorescence; most USNCs gain in vivo renal clearance capability to guarantee safety. Therefore, USNCs could be promising safe materials for biomedical applications. In this mini-review, we summarize recent advances in the controlled synthesis, assembly, and biomedical applications of USNCs. We also discussed future challenges and perspectives in the development of USNC-based nanomedicine.

Graphical abstract: Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications

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Article information


Submitted
27 Sep 2018
Accepted
12 Nov 2018
First published
13 Nov 2018

Biomater. Sci., 2019,7, 480-489
Article type
Minireview

Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications

Q. Wang, S. Wang, X. Hu, F. Li and D. Ling, Biomater. Sci., 2019, 7, 480
DOI: 10.1039/C8BM01200H

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