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Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications

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Abstract

Inorganic nanomaterials have been studied extensively in recent years because of their unique physical and chemical characteristics. Moreover, ultra-small nanoclusters (USNCs), which are less than 3 nm in size, exhibit extraordinary properties different from those of larger-sized nanoparticles. For example, ultra-small iron oxide nanoclusters (NCs) show paramagnetic properties; ultra-small noble metal NCs exhibit bright fluorescence; most USNCs gain in vivo renal clearance capability to guarantee safety. Therefore, USNCs could be promising safe materials for biomedical applications. In this mini-review, we summarize recent advances in the controlled synthesis, assembly, and biomedical applications of USNCs. We also discussed future challenges and perspectives in the development of USNC-based nanomedicine.

Graphical abstract: Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications

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Publication details

The article was received on 27 Sep 2018, accepted on 12 Nov 2018 and first published on 13 Nov 2018


Article type: Minireview
DOI: 10.1039/C8BM01200H
Citation: Biomater. Sci., 2019, Advance Article
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    Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications

    Q. Wang, S. Wang, X. Hu, F. Li and D. Ling, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C8BM01200H

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