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Polypeptide-affined interpenetrating hydrogels with tunable physical and mechanical properties

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Abstract

Novel hydrogels with tunable mechanical properties similar to human soft tissue have increasing applications in biomedicine, soft robotics, and biocompatible electronics. However, most of these materials require multiple-step fabrication, are not robust, and compromise bioactivity. Thus, aiming to address these shortfalls, herein, we report a versatile hydrogel system with tunable properties and a facile one-pot fabrication process. The hydrogel system is comprised of a hydrogen-bonded hydrophilic polyurethane (HPU) network and a loosely crosslinked copolymer crosslinked with long chain crosslinkers and decorated with succinimide groups. The active succinimide sites conjugate to proteins, such as bovine serum albumin as a model protein, providing additional biocompatibility and controlled release of growth factors and peptides. The interpenetrating nature of this hydrogel system provides a high degree of freedom over mechanical and physical properties by adjusting the ratio of networks and the composition of the second network. Through this process, a library of biocompatible hydrogels with stiffness ranging from 1 to more than 200 kPa was developed. Moreover, it was found that the succinimide groups impact the degree of crosslinking and contribute to the controlled release of peptides.

Graphical abstract: Polypeptide-affined interpenetrating hydrogels with tunable physical and mechanical properties

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Publication details

The article was received on 25 Sep 2018, accepted on 23 Nov 2018 and first published on 26 Nov 2018


Article type: Paper
DOI: 10.1039/C8BM01182F
Citation: Biomater. Sci., 2019, Advance Article
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    Polypeptide-affined interpenetrating hydrogels with tunable physical and mechanical properties

    F. Oveissi, S. Naficy, T. Y. L. Le, D. F. Fletcher and F. Dehghani, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C8BM01182F

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