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Well-ordered mesoporous silica and bioactive glasses: promise for improved hemostasis

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Abstract

Immediate control of uncontrolled bleeding and infection are essential for saving lives in both combat and civilian arenas. Inorganic well-ordered mesoporous silica and bioactive glasses have recently shown great promise for accelerating hemostasis and infection control. However, to date, there has been no comprehensive report assessing their specific mechanism of action in accelerating the hemostasis process and exerting an antibacterial effect. After providing a brief overview of the hemostasis process, this review presents a critical overview of the recently developed inorganic mesoporous silica and bioactive glass-based materials proposed for hemostatic clinical applications and specifically investigates their unique characteristics that render them applicable for hemostatic applications and preventing infections. This article also identifies promising new research directions that should be undertaken to ascertain the effectiveness of these materials for hemostatic applications.

Graphical abstract: Well-ordered mesoporous silica and bioactive glasses: promise for improved hemostasis

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Publication details

The article was received on 28 Aug 2018, accepted on 05 Oct 2018 and first published on 05 Oct 2018


Article type: Review Article
DOI: 10.1039/C8BM01041B
Citation: Biomater. Sci., 2019, Advance Article
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    Well-ordered mesoporous silica and bioactive glasses: promise for improved hemostasis

    S. Pourshahrestani, N. A. Kadri, E. Zeimaran and M. R. Towler, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C8BM01041B

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