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A novel high pH-sensitive nitrogen-doped yellow fluorescent carbon dots based one-step synthesis and detection application in living cells

Abstract

Monitoring the pH in living cells is of great significance for deeper understanding cellular functions as well diseases diagnosis. Herein, a rare example of N-doped carbon dots (N-CDs) that emit bright-yellow fluorescence is reported using o-phenylenediamine as carbon precursor by a simple one-pot hydrothermal method. The prepared N-CDs exhibit not only highly optical stabilities and good biocompatibility but also pH sensitivity. A good linear relationship between the fluorescence intensity and the pH value could be obtained in the range of 4.2 to 7.0 (R2 = 0.9983). In addition, the N-CDs also possess superior selectivity of hydrogen ions over common metal ions and some bioactive molecules. On this basis, the N-CDs are successfully applied to cellular imaging and monitor pH fluctuations in living cells.

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Publication details

The article was received on 20 Aug 2019, accepted on 16 Sep 2019 and first published on 10 Oct 2019


Article type: Paper
DOI: 10.1039/C9AY01794A
Anal. Methods, 2019, Accepted Manuscript

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    A novel high pH-sensitive nitrogen-doped yellow fluorescent carbon dots based one-step synthesis and detection application in living cells

    L. Shen, C. Hou, J. Li, X. Wang, Y. Zhao, H. Yang, S. Yang, M. Yang, X. Luo and D. Huo, Anal. Methods, 2019, Accepted Manuscript , DOI: 10.1039/C9AY01794A

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