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Issue 41, 2019
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A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection

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Abstract

A fast SERS and colorimetric dual-modal assay for thiol detection was developed using an unsaturated triosmium carbonyl cluster, Os3(CO)10(μ-H)2, as a detection probe. The cluster undergoes a distinct color change in the presence of thiol and the SERS spectrum shows a shift in the CO stretching vibration, located in a silent region where there is no interference from biomolecules. Such assay offers high sensitivity with a detection limit up to 0.1 μM by SERS.

Graphical abstract: A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection

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Publication details

The article was received on 09 Jul 2019, accepted on 01 Oct 2019 and first published on 03 Oct 2019


Article type: Communication
DOI: 10.1039/C9AY01466G
Anal. Methods, 2019,11, 5232-5236

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    A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection

    D. Lin, J. Zhou, Y. Yu, W. Chen, P. Liao, H. Huang and K. V. Kong, Anal. Methods, 2019, 11, 5232
    DOI: 10.1039/C9AY01466G

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