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Alizarin Red–Tb3+ complex as a ratiometric colorimetric and fluorescent dual probe for the smartphone-based detection of an anthrax biomarker

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Abstract

In this work, a novel dual-sensing probe was developed for detecting an anthrax biomarker (dipicolinic acid, DPA) based on the competitive coordination of Tb3+ between DPA and Alizarin Red (AR). UV-vis titration experiments demonstrated that AR and Tb3+ ions formed a 3 : 1 coordination pair in a boric acid–borate buffer solution. However, the subsequent addition of DPA to the complex solution destroyed the coordination of AR–Tb3+ completely, resulting in the formation of DPA–Tb3+. This constructed a new mechanism of ratiometric colorimetric and fluorescence dual-mode sensing for DPA. By integrating a smartphone with an easy-to-access color-scanning APP, this dual-sensing method could be further applied as a reliable scanometric assay for the rapid and on-site visible detection of DPA directly. With the method established by us, the sensitive and selective detection of DPA released from bacterial spores could be realized easily.

Graphical abstract: Alizarin Red–Tb3+ complex as a ratiometric colorimetric and fluorescent dual probe for the smartphone-based detection of an anthrax biomarker

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Publication details

The article was received on 12 Jun 2019, accepted on 24 Jul 2019 and first published on 24 Jul 2019


Article type: Paper
DOI: 10.1039/C9AY01235D
Anal. Methods, 2019, Advance Article

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    Alizarin Red–Tb3+ complex as a ratiometric colorimetric and fluorescent dual probe for the smartphone-based detection of an anthrax biomarker

    M. Xu, W. Huang, D. Lu, C. Huang, J. Deng and T. Zhou, Anal. Methods, 2019, Advance Article , DOI: 10.1039/C9AY01235D

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