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Silver Nanoparticle-Supported Hydroxyapatite as Material for Visual Detection of Urinary Cysteine

Abstract

A new approach for colorimetric detection of cysteine in urine sample has been established based on the aggregations of silver nanoparticles (AgNPs) on hydroxyapatite (HAp). The silver ion-modified hydroxyapatite (Ag-HAp) via ion-exchange was used to extract cysteine in samples and a formation of AgNPs, confirmed by Transmission Electron Microscopy (TEM), occurred after NaBH4 treatment. Different cluster sizes of AgNPs on HAp resulting from various amounts of cysteine induced a color change from yellow to pink or violet as concentration of cysteine increased. The linear range for cysteine determination was in the range of 0-105 µM with a detection limit of 2.03 µM. Sample pretreatment and standard addition allowed detection of cysteine in urine samples, and the percentage of recovery in the range of 94.4 to 102.8 % was obtained.

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Publication details

The article was received on 06 Apr 2019, accepted on 24 Apr 2019 and first published on 01 May 2019


Article type: Paper
DOI: 10.1039/C9AY00725C
Anal. Methods, 2019, Accepted Manuscript

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    Silver Nanoparticle-Supported Hydroxyapatite as Material for Visual Detection of Urinary Cysteine

    R. Prasetia, S. Fuangswasdi and F. Unob, Anal. Methods, 2019, Accepted Manuscript , DOI: 10.1039/C9AY00725C

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