Fabrication of antibiotics sensitive 2D-molecularly imprinted photonic crystal
A molecularly imprinted colloidal array (MICA) for the detection of clindamycin hydrochloride (CLI) was prepared by embedding a two-dimension (2-D) polystyrene crystalline colloidal array within a CLI imprinted hydrogel. The MICA showed significant response to CLI, the particle spacing of the MICA changed 41nm within 10min in response to 1mM CLI, and the structural color of the MICA changed from blue, green, to yellow, and finally, to red. In further, MICA was also used to detect the similar antibiotics, lincomycin, which had only 10nm spacing change. The MICA can be reused for more than 5 times. This low-cost and naked-eye sensing material provides a label free way to detect CLI and other antibiotic.