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Issue 18, 2019
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A turn-on near-infrared fluorescent probe with rapid response and large Stokes shift for the selective and sensitive detection of zinc(ii) and its application in living cells

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Abstract

Herein, a new near-infrared turn-on fluorescent probe, YPT, was designed and synthesized for the rapid detection of Zn2+, which exhibited low limit of detection for Zn2+ (12 nM) as well as a favorable large Stokes shift (λemλex = 168 nm). In addition, the probe showed rapid detection progress within 30 s, accompanied by a distinct change in fluorescence from colorless to bright red. Moreover, the sensing mechanism of YPT towards Zn2+ was supported by the Job's plot, HR-MS analysis, 1H NMR titration analysis and density functional theory (DFT) results. In addition, YPT was applied as a visible test strip for the detection of Zn2+. Finally, the NIR fluorescence imaging of Zn2+ was successfully performed in living cells using this probe. All the results indicate that this probe can be used to detect Zn2+ in both solution and living systems.

Graphical abstract: A turn-on near-infrared fluorescent probe with rapid response and large Stokes shift for the selective and sensitive detection of zinc(ii) and its application in living cells

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Supplementary files

Article information


Submitted
22 Feb 2019
Accepted
02 Apr 2019
First published
03 Apr 2019

Anal. Methods, 2019,11, 2396-2403
Article type
Paper

A turn-on near-infrared fluorescent probe with rapid response and large Stokes shift for the selective and sensitive detection of zinc(II) and its application in living cells

W. Zhang, X. Jin, W. Chen, C. Jiang and H. Lu, Anal. Methods, 2019, 11, 2396
DOI: 10.1039/C9AY00380K

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