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An effective approach to the quantitative analysis of the skin-whitening agents in cosmetics with different substrates based on conventional UV-Vis determination

Abstract

Although UV-Vis spectra have been applied to many fields, it still encounters some challenges in multi-component mixtures analysis due to serious spectral overlapping and different interferences. In this paper, Tchebichef curve moment (TM) approach was developed and proposed for the quantitative analysis of the five skin-whitening agents in several cosmetic products with different substrates based on conventional UV-Vis determination for the first time. First, the TMs were calculated from the raw UV-Vis spectra of mixed standard samples, and employed to establish the linear quantitative models by stepwise regression. Then, the obtained models were applied to the analysis of real samples. The leave-one-out correlation coefficients (Rloo-cv) of the established models were more than 0.9948 within the linear ranges. The proposed approach was evaluated by intra-, inter-day precision (less than 5.98%) and recovery (ranged from 88.3±2.8% to 109.2±2.3%). The LODs and LOQs were less than 0.13 mg L-1 and 0.45 mg L-1, respectively. Compared with the classical methods, the proposed approach is not only more accurate, reliable and robust in the quality control analysis of cosmetic products, but also can extend effectively the application of conventional UV-Vis determination.

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Publication details

The article was received on 02 Jan 2019, accepted on 11 Feb 2019 and first published on 12 Feb 2019


Article type: Paper
DOI: 10.1039/C9AY00007K
Citation: Anal. Methods, 2019, Accepted Manuscript

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    An effective approach to the quantitative analysis of the skin-whitening agents in cosmetics with different substrates based on conventional UV-Vis determination

    S. S. Li, B. Yin, H. L. Zhai, S. H. Lu and J. Y. Mi, Anal. Methods, 2019, Accepted Manuscript , DOI: 10.1039/C9AY00007K

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