Issue 10, 2019
From the journal:

Analytical Methods

A 6-acetyl-2-naphthol based two-photon fluorescent probe for the selective detection of nitroxyl and imaging in living cells†

Pingzhu Zhang,ab   Pingping Lian,a   Xiaofen Wang,a   Xueyan Li,a   Chao Wei ORCID logo *ab  and  Xiaoliu Li*ab  

* Corresponding authors

a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China
E-mail: weichao@hbu.edu.cn, lixl@hbu.cn

b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, P. R. China

Abstract

A novel two-photon HNO fluorescent probe (TP-HNO) was easily constructed and prepared by combining 6-acetyl-2-naphthol and 2-(diphenylphosphino)-benzoate. TP-HNO exhibited high selectivity (more than 140-fold off–on fluorescence response) and high sensitivity (the detection limit is 78 nM) to HNO in solution. TP-HNO was also applied for two-photon imaging of HNO in living cells and in tissues.

Graphical abstract: A 6-acetyl-2-naphthol based two-photon fluorescent probe for the selective detection of nitroxyl and imaging in living cells

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C8AY02819B
Article type
Communication
Submitted
27 Dec 2018
Accepted
11 Feb 2019
First published
12 Feb 2019

Anal. Methods, 2019,11, 1299-1303

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A 6-acetyl-2-naphthol based two-photon fluorescent probe for the selective detection of nitroxyl and imaging in living cells

P. Zhang, P. Lian, X. Wang, X. Li, C. Wei and X. Li, Anal. Methods, 2019, 11, 1299 DOI: 10.1039/C8AY02819B

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