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Issue 6, 2019
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Label free electrochemical detection of cardiac biomarker troponin T using ZnSnO3 perovskite nanomaterials

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Abstract

This paper reports label free sub-femtomolar detection of cardiac biomarker troponin T using ZnSnO3 perovskite nanomaterial based electrochemical biosensors. Herein, we have demonstrated two separate synthesis schemes for the perovskite material, one being a hydrothermal synthesis method, and the other being electrochemical deposition. In this work, for the electrochemical detection of troponin T with the hydrothermally synthesized ZnSnO3, we have used a glassy carbon electrode (GCE), on to which the nanomaterials are dropcasted so as to create a heterogeneous working electrode. In a separate scheme, we have used indium tin oxide coated polyethylene terephthalate (ITO/PET) substrates as the working electrodes, on to which a thin film of ZnSnO3 nanomaterial has been deposited electrochemically. Subsequently, the capture antibodies corresponding to the targeted cardiac troponin T are immobilized on to the surface functionalized working electrodes using NHS/EDC chemistry. The electrochemical detection of the target analyte has been performed in the concentration range of 1 fg mL−1 to 1 μg mL−1, using electrochemical impedance spectroscopy. For the GCE and ITO/PET based bioelectrodes, the approximated limits of detection are found to be 0.187 fg mL−1 and 0.571 fg mL−1 respectively, whereas the respective values of sensitivity of the same are 35.25 kΩ (μg mL−1)−1 cm−2 and 8.813 kΩ (μg mL−1)−1 cm−2.

Graphical abstract: Label free electrochemical detection of cardiac biomarker troponin T using ZnSnO3 perovskite nanomaterials

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Publication details

The article was received on 30 Nov 2018, accepted on 04 Jan 2019 and first published on 04 Jan 2019


Article type: Paper
DOI: 10.1039/C8AY02617C
Citation: Anal. Methods, 2019,11, 744-751

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    Label free electrochemical detection of cardiac biomarker troponin T using ZnSnO3 perovskite nanomaterials

    P. Supraja, V. Sudarshan, S. Tripathy, A. Agrawal and S. G. Singh, Anal. Methods, 2019, 11, 744
    DOI: 10.1039/C8AY02617C

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