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Efficient “Ratiometric” fluorescence chemosensor for selective detection of Hg2+ ions based on phosphonates: its live cell imaging and molecular keypad lock applications

Abstract

We report that the smart chemosensors (L1 and L2) can detect Hg2+ ion selectively over other metal ions was studied by various spectral techniques. Particularly, the proposed chemosensors exhibiting the notable color and spectra changes with the addition of mercury ions. Moreover, the colorimetric and fluorescence could be reversed with the addition of EDTA into the L1-Hg2+ and L2-Hg2+ solutions. Based on the admirable reversibility process, we displayed a molecular-scale sequential information processing circuit proposed the “Writing-Reading-Erasing-Reading” and “Multi-write” behaviors in the form of binary logic. Furthermore, L1 and L2 mimic as a molecular keypad lock and molecular logic gates with the successive addition of Hg2+ and EDTA. The binding ability of Hg2+ ion with L1 and L2 was further demonstrated by Density Functional Theory (DFT) studies. The biocompatibility of these chemosensors is successfully used for live cell imaging of Hg2+ in HeLa cells under the experimental conditions. Furthermore, the sensors L1 and L2 were also useful to determine the concentration of Hg2+ ion in real water samples to exhibit its practical applications.

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Publication details

The article was received on 13 Nov 2018, accepted on 09 Jan 2019 and first published on 09 Jan 2019


Article type: Paper
DOI: 10.1039/C8AY02483A
Citation: Anal. Methods, 2019, Accepted Manuscript
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    Efficient “Ratiometric” fluorescence chemosensor for selective detection of Hg2+ ions based on phosphonates: its live cell imaging and molecular keypad lock applications

    G. G. Vinoth Kumar, S. K. Ramaraj, T. C.-K. Yang, R. Jegathalaprathaban and S. Gandhi, Anal. Methods, 2019, Accepted Manuscript , DOI: 10.1039/C8AY02483A

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