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Spontaneous reduction of KMnO4 with MoS2 quantum dots for glutathione sensing in tumors

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Abstract

Transition-metal dichalcogenides (TMDCs) have attracted a lot of attention due to their electronic, optical, mechanical, and catalytic properties. In addition, TMDCs possess rich redox chemistry that enables the decoration of metal nanoparticles directly on their surfaces. In this paper, MnO2/MoS2 nanocomplexes were obtained by the spontaneous reduction of KMnO4 with MoS2 QDs as the reductive agent. The formed MnO2/MoS2 nanocomplexes exhibited activated fluorescence and MR imaging signal in the presence of glutathione (GSH). After conjugation with an AS1411 aptamer, specific in vivo MR imaging and fluorescence labeling of the 786-O tumor cells were realized, showing their promising potential for biomedical applications.

Graphical abstract: Spontaneous reduction of KMnO4 with MoS2 quantum dots for glutathione sensing in tumors

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Publication details

The article was received on 08 Nov 2019, accepted on 28 Nov 2019 and first published on 28 Nov 2019


Article type: Paper
DOI: 10.1039/C9AN02239B
Analyst, 2020, Advance Article

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    Spontaneous reduction of KMnO4 with MoS2 quantum dots for glutathione sensing in tumors

    Y. Wang, L. Cai, Q. Wang, M. Zhao, L. Dong, K. Xu and J. Li, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02239B

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