Jump to main content
Jump to site search


The Amplified Electrochemiluminescence Signals Promoted by AIE-Active Moiety of D-A Type Polymer Dots for Biosensing

Abstract

Three-component conjugated polymers with strong donor-acceptor (D-A) type could be synthesized by Pd-catalyzed Suzuki coupling polymerization reaction of 1,2-bis(4-bromophenyl)-1,2-diphenylethene (M-1) with 9-octyl-3,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole (M-2) and 4,6-bis((E)-4-bromostyryl)-2,2-difluoro-5-phenyl-2H-1l3,3,2l4-dioxaborinine (M-3). Among them, P-1 and P-2 containing high TPE ratios at 0.95 and 0.9 showed obvious aggregation-induced emission (AIE) behavior, on the contrary P-3 containing low TPE ratio at 0.8 appeared aggregation-caused quenching (ACQ) phenomenon. Especially, three resulting polymer dots (P-1 to P-3 Pdots) gave 200 mV lower electrochemiluminescence (ECL) potential due to their strong D-A electronic structure. Most importantly, the ECL signals of Pdots could be enhanced as high as 3 times by increasing their AIE-active TPE moiety ratios from 0.8 (P-3) to 0.95 (P-1) via band gap emission process. Herein, P-1 Pdots with the strongest ECL signal was successfully applied as the ECL biosensor for the detection of catechol, epinephrine and dopamine with the detection limits for 1, 7 and 3 nM, respectively. This work provides a new strategy for developing highly sensitive ECL biosensors by the smart structure design of the AIE-active Pdots.

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Oct 2019, accepted on 08 Nov 2019 and first published on 08 Nov 2019


Article type: Paper
DOI: 10.1039/C9AN01992H
Analyst, 2019, Accepted Manuscript

  •   Request permissions

    The Amplified Electrochemiluminescence Signals Promoted by AIE-Active Moiety of D-A Type Polymer Dots for Biosensing

    Z. Wang, N. Wang, H. Gao, Y. Quan, H. Ju and Y. Cheng, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C9AN01992H

Search articles by author

Spotlight

Advertisements