Jump to main content
Jump to site search


The fabrication of gold nanoelectrode-nanopore nanopipette for dopamine enrichment and multimode detection

Abstract

It is important to further improve the electrophysiology and electrochemistry techniques of neurotransmitter detection. Here, we report the development of multifunctional nanopipette-based integrated approaches for the detection of neurotransmitters. We successfully fabricated a nanopipette with two independent functional units at the apex, a nanopore and a gold nanoelectrode (GNE). The GNE shows good electrochemical reponse to dopamine (DA). Further, both the nanopore and nanoelectrode can effectively enrich dopamine (DA) but not ascorbic acid by electrical means. The enriched DAs are then detected and analyzed with obviously improved signal-to-noise ratio by electrochemical methods and Surface-enhanced Raman spectroscopy (SERS). In addition, with the addition of silver nanoparticles during enrichment, up to 10 times increase of Raman intensity of DA can be observed.

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Oct 2019, accepted on 24 Nov 2019 and first published on 25 Nov 2019


Article type: Paper
DOI: 10.1039/C9AN01990A
Analyst, 2019, Accepted Manuscript

  •   Request permissions

    The fabrication of gold nanoelectrode-nanopore nanopipette for dopamine enrichment and multimode detection

    D. Yang, G. Liu, H. Li, A. Liu, J. Guo, Y. Shan, Z. Wang and J. He, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C9AN01990A

Search articles by author

Spotlight

Advertisements