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Enzymatic reaction-based nanopore detection of zinc ions

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Abstract

We report a label-free nanopore sensor for the detection of Zn2+ ions. By taking advantage of the cleavage of a substrate peptide by zinc-dependent enzymes, nanomolar concentrations of Zn2+ ions could be detected within minutes. Furthermore, structurally similar transition metals such as Ni2+, Co2+, Hg2+, Cu2+, and Cd2+ did not interfere with their detection. The enzymatic reaction-based nanopore sensing strategy developed in this work may find potential applications in environmental monitoring and medical diagnosis.

Graphical abstract: Enzymatic reaction-based nanopore detection of zinc ions

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Publication details

The article was received on 11 Sep 2019, accepted on 17 Oct 2019 and first published on 18 Oct 2019


Article type: Paper
DOI: 10.1039/C9AN01784D
Analyst, 2019, Advance Article

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    Enzymatic reaction-based nanopore detection of zinc ions

    G. M. Roozbahani, Y. Zhang, X. Chen, M. H. Soflaee and X. Guan, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN01784D

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