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Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Abstract

Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

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Publication details

The article was received on 05 Sep 2019, accepted on 28 Nov 2019 and first published on 28 Nov 2019


Article type: Paper
DOI: 10.1039/C9AN01748H
Analyst, 2019, Accepted Manuscript

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    Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

    S. Mabbott, S. C. Fernandes, M. Schechinger, G. Cote, K. Faulds, C. R. Mace and D. Graham, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C9AN01748H

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