Jump to main content
Jump to site search


Yolk−shell structured Au@Ag@mSiO2 as probe for sensing of cysteine enantiomers and Cu2+ based on circular dichroism

Abstract

A yolk−shell structured Au@Ag@mSiO2 probe was fabricated by coating a layer of mesoporous silica on the surface of Au@Ag core-shell nanosphere, followed by partially removing the Ag shell. Mirror symmetrical chiral signals at ~258 nm in the UV region were observed for the probe upon coupling with cysteine enantiomers on the surface of Au@Ag. The intensity of the CD signal of the probe is enhanced with increasing L/D-Cys concentration, allowing the quantitatively determination of the cysteine enantiomers. The developed method exhibits an excellent linear relationship between the CD signal and L-Cys concentration ranging from 10 μM to 90 μM with a limit of detection of 8.5 μM. In the presence of Cu2+, the CD signal of probe was weakened due to the oxidation of L-cysteine to L-cystine catalyzed by Cu2+. Based on this phenomenon, a new strategy for detection of Cu2+ can be established. Under optimized condition, the CD signal decreases linearly with the log of the concentration of Cu2+ in the range from 1 to 250 nM with a detection limit of 0.1 nM.

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Aug 2019, accepted on 22 Oct 2019 and first published on 23 Oct 2019


Article type: Paper
DOI: 10.1039/C9AN01541H
Analyst, 2019, Accepted Manuscript

  •   Request permissions

    Yolk−shell structured Au@Ag@mSiO2 as probe for sensing of cysteine enantiomers and Cu2+ based on circular dichroism

    J. Wang, X. Xu, X. Qiu, S. Zhang and Y. Peng, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C9AN01541H

Search articles by author

Spotlight

Advertisements