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A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells

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Abstract

A novel pH-sensitive fluorescent probe has been designed and synthesized for sensing intracellular pH. This probe showed excellent water solubility, it was sensitive toward the pH range from 4 to 12, and it was especially sensitive in alkaline environments. During the pH changes from acidic to alkaline environments, the color of the solution turned from yellow to purple, thus the difference in color can be used to distinguish between acidic and alkaline systems. The other major features of probe pH-DCN including high selectivity, low toxicity, good reversibility and stability allowed pH-DCN to visualize fluctuations of the pH in live cells. Moreover, probe pH-DCN has successfully discriminated cancer cells from normal cells by monitoring their different intracellular pH levels.

Graphical abstract: A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells

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Publication details

The article was received on 07 Aug 2019, accepted on 23 Sep 2019 and first published on 27 Sep 2019


Article type: Paper
DOI: 10.1039/C9AN01504C
Analyst, 2019, Advance Article

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    A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells

    Z. Li, C. Yu, Y. Chen, Z. Zhuang, B. Tian, C. Liu, P. Jia, H. Zhu, W. Sheng and B. Zhu, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN01504C

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