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Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry

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Abstract

G-quadruplex (G4) nucleic acid structures are involved in a number of different diseases and their drug-induced stabilization is deemed to be a promising therapeutic approach. Herein is reported a proof of principle study on the use of nano differential scanning fluorimetry for a rapid and accurate analysis of G4-stabilizing ligands, exploiting the fluorescence properties of a 2-aminopurine modified G4-forming oligonucleotide.

Graphical abstract: Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry

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Publication details

The article was received on 01 Aug 2019, accepted on 04 Oct 2019 and first published on 07 Oct 2019


Article type: Communication
DOI: 10.1039/C9AN01463B
Analyst, 2019, Advance Article

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    Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry

    B. Pagano, N. Iaccarino, A. Di Porzio, A. Randazzo and J. Amato, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN01463B

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