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Ambient Mass Spectrometry for Molecular Diagnosis of Lung Cancer

Abstract

Lung cancer is one of the worldwide most common malignancies and the leading causes of cancer-related death. Among the technologies suitable for rapid and accurate molecular diagnosis of lung cancer, ambient mass spectrometry (AMS) gains increasing interest as it allows direct profiling of molecular information from various biological samples (e.g., tissue, serum, urine and sputum) in real-time and with minimal or no sample pretreatment. This minireview summarizes the applications of AMS in lung cancer studies (including tissue molecular identification, discovery of potential biomarkers, surgical margin assessment. etc.), and discusses the challenges and perspectives of AMS in clinical precision molecular diagnosis of lung cancer.

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Publication details

The article was received on 19 Jul 2019, accepted on 25 Nov 2019 and first published on 27 Nov 2019


Article type: Minireview
DOI: 10.1039/C9AN01365B
Analyst, 2019, Accepted Manuscript

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    Ambient Mass Spectrometry for Molecular Diagnosis of Lung Cancer

    H. Lu, H. Zhang, Y. Wei and H. Chen, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C9AN01365B

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