Ambient Mass Spectrometry for Molecular Diagnosis of Lung Cancer
Lung cancer is one of the worldwide most common malignancies and the leading causes of cancer-related death. Among the technologies suitable for rapid and accurate molecular diagnosis of lung cancer, ambient mass spectrometry (AMS) gains increasing interest as it allows direct profiling of molecular information from various biological samples (e.g., tissue, serum, urine and sputum) in real-time and with minimal or no sample pretreatment. This minireview summarizes the applications of AMS in lung cancer studies (including tissue molecular identification, discovery of potential biomarkers, surgical margin assessment. etc.), and discusses the challenges and perspectives of AMS in clinical precision molecular diagnosis of lung cancer.