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Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

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Abstract

Biological organisms represent highly dynamic systems, which are continually exposed to environmental factors and always strive to restore steady-state homeostasis. Posttranslational modifications are key regulators with which biological systems respond to external stimuli. To understand how homeostasis is restored, it is important to study the kinetics of posttranslational modifications. In this review we discuss proteomic approaches using stable isotope labeled metabolic precursors to study dynamics of posttranslational modifications in cell culture.

Graphical abstract: Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

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Publication details

The article was received on 05 Jul 2019, accepted on 13 Oct 2019 and first published on 25 Oct 2019


Article type: Critical Review
DOI: 10.1039/C9AN01258C
Analyst, 2019, Advance Article

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    Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

    A. van Pijkeren, R. Bischoff and M. Kwiatkowski, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN01258C

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