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Triphenylamine Schiff base as a lipid droplet-targeted fluorescent probe using Si–O–Si as a bridge for the detection of Cr6+ applied in bio-imaging

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Abstract

Lipid droplets are known to play an important role in many cellular activities, as revealed by recent studies. Additionally, hexavalent chromium is considered extremely toxic because it readily passes through cellular membranes and easily accumulates in living cells. In this study, a novel lipid droplet-targeted fluorescent probe (Si-LDS) for recognition of Cr6+ in living cells was designed and synthesized using triphenylamine derivatives and organosiloxane. Si-LDS detected Cr6+ with high selectivity and sensitivity. The novel probe was successfully applied to cell imaging of exogenous Cr6+ in HeLa cells, and Si-LDS was able to localize mainly in the lipid droplets of HeLa cells. Si-LDS is the first lipid droplet-targeted fluorescent probe for monitoring Cr6+.

Graphical abstract: Triphenylamine Schiff base as a lipid droplet-targeted fluorescent probe using Si–O–Si as a bridge for the detection of Cr6+ applied in bio-imaging

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Publication details

The article was received on 26 Jun 2019, accepted on 23 Jul 2019 and first published on 25 Jul 2019


Article type: Communication
DOI: 10.1039/C9AN01174A
Analyst, 2019, Advance Article

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    Triphenylamine Schiff base as a lipid droplet-targeted fluorescent probe using Si–O–Si as a bridge for the detection of Cr6+ applied in bio-imaging

    X. Wang, Y. Zuo, Y. Zhang, T. Yang and W. Lin, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN01174A

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