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Towards precision medicine: the role and potential of protein and peptide microarrays

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Abstract

Although the traditional strategy of developing general medical treatments for heterogeneous patient populations has a well-established track record, the acknowledgment that one-size-does-not-fit-all is pushing health-care to enter a new era of tailored interventions. The advent of precision medicine is fueled by the high-throughput analysis of individual DNA variants and mRNA expression profiles. However, due to the role of proteins in providing a more direct view of disease states than genomics alone, the ability to comprehensively analyze protein alterations and post translational modifications (PTMs) is a necessary step to unravel disease mechanisms, develop novel biomarkers and targeted therapies. Protein and peptide microarrays can play a major role in this frame, due to high-throughput, low sample consumption and wide applicability. Here, their current role and potentialities are discussed through the review of some promising applications in the fields of PTMs analysis, enzyme screening, high-content immune-profiling and the phenotyping of extracellular vesicles.

Graphical abstract: Towards precision medicine: the role and potential of protein and peptide microarrays

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Publication details

The article was received on 21 Jun 2019, accepted on 27 Jul 2019 and first published on 31 Jul 2019


Article type: Critical Review
DOI: 10.1039/C9AN01142K
Analyst, 2019, Advance Article

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    Towards precision medicine: the role and potential of protein and peptide microarrays

    D. Brambilla, M. Chiari, A. Gori and M. Cretich, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN01142K

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