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Issue 18, 2019
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Detection of codeine and fentanyl in saliva, blood plasma and whole blood in 5-minutes using a SERS flow-separation strip

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Abstract

A simple-to-use device to measure drugs in saliva, blood plasma, and whole blood for point-of-care analysis and treatment of overdose patients has been investigated. A rudimentary flow strip has been developed to separate opioids from these biofluids for analysis by surface-enhanced Raman spectroscopy (SERS). The strips are based on lateral flow assays, in which the antibodies have been substituted by SERS-active pads for detection. Samples of codeine and fentanyl, artificially added to these biofluids, were measured using the strips by a field-usable Raman spectrometer. We report measurement of these drugs in these biofluids from 0.5 to 5 μg mL−1 in 5 minutes. Calculated limits of detection for the spectra suggest that these drugs could be measured at 5 to 20 ng mL−1 with improvements in the strips’ separation capability.

Graphical abstract: Detection of codeine and fentanyl in saliva, blood plasma and whole blood in 5-minutes using a SERS flow-separation strip

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Publication details

The article was received on 13 Jun 2019, accepted on 11 Aug 2019 and first published on 12 Aug 2019


Article type: Paper
DOI: 10.1039/C9AN01087D
Analyst, 2019,144, 5449-5454

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    Detection of codeine and fentanyl in saliva, blood plasma and whole blood in 5-minutes using a SERS flow-separation strip

    C. Shende, C. Brouillette and S. Farquharson, Analyst, 2019, 144, 5449
    DOI: 10.1039/C9AN01087D

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