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Portable linear ion trap mass spectrometer with compact multistage vacuum system and continuous atmospheric pressure interface

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Abstract

A portable linear ion trap mass spectrometer featuring a compact three-stage vacuum system, a continuous atmospheric pressure interface (CAPI), and a miniature ion funnel was developed and characterized. The dimensions and weight of the instrument were 38 × 26 × 23 cm3 and ∼20 kg, respectively. The combination of a three-stage vacuum system and CAPI reduced the pressure smoothly from atmospheric to ∼5 × 10−4 Torr, ensuring that the miniature ion funnel, quadrupole ion guide, and linear ion trap operated in a suitable and stable vacuum environment. The analytical performance of the instrument was evaluated with a nano-electron spray ionization source and a reserpine sample solution. A satisfactory mass resolution up to 4060 (mm, FWHM) was achieved at m/z 609 when the mass scan rate was 495 Da s−1. Unit mass resolution was achieved at a mass scan rate of 6000 Da s−1. In addition, a limit of detection of 5 ng mL−1 was achieved and tandem mass spectrometry (MS3) was successfully performed with the instrument. Furthermore, the measurements showed high repeatability and stability (RSD < 6%). This portable mass spectrometer shows great potential for practical applications in on-site analyses, such as those required for food safety, drug analysis, environmental protection, forensic investigations, and homeland security.

Graphical abstract: Portable linear ion trap mass spectrometer with compact multistage vacuum system and continuous atmospheric pressure interface

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Publication details

The article was received on 06 Jun 2019, accepted on 15 Jul 2019 and first published on 16 Jul 2019


Article type: Paper
DOI: 10.1039/C9AN01047E
Analyst, 2019, Advance Article

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    Portable linear ion trap mass spectrometer with compact multistage vacuum system and continuous atmospheric pressure interface

    X. Li, Y. Zhang, S. Ge, J. Qian and W. Miao, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN01047E

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