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Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis

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Abstract

Analysis of metabolites in biofluids using nuclear magnetic resonance often requires the suppression of obscuring signals arising from water and macromolecules. This paper analyses the limitations of the pulse sequence most commonly used to achieve such suppression (presat-CPMG) and proposes new pulse sequences that do not share those limitations. The utility of these improved pulse sequences is demonstrated in a metabolomic study of multiple sclerosis (MS) patients.

Graphical abstract: Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis

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Publication details

The article was received on 31 May 2019, accepted on 15 Oct 2019 and first published on 06 Nov 2019


Article type: Paper
DOI: 10.1039/C9AN01005J
Analyst, 2019, Advance Article

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    Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis

    J. A. Aguilar, J. Cassani, F. Probert, J. Palace, T. D. W. Claridge, A. Botana and A. M. Kenwright, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN01005J

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