Analysis of genome-wide in cell free DNA methylation: progress and prospect

Zhiyu Liu; Zexin Wang; Erteng Jia; Tinglan Ouyang; Min Pan; Jiafeng Lu; Qinyu Ge; Yunfei Bai

doi:10.1039/C9AN00935C

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Analysis of genome-wide in cell free DNA methylation: progress and prospect

Zhiyu Liu,

^a Zexin Wang,

^a Erteng Jia,

^a Tinglan Ouyang,^a Min Pan,^a Jiafeng Lu,^b Qinyu Ge

*^a and Yunfei Bai

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
E-mail: whitecf@seu.edu.cn

^b Center of Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215002, China

Abstract

DNA methylation is an important epigenetic marker that affects gene expression. Cell-free DNA methylation detection is a promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. This review summarizes the existing literature and reviews on the detection methods based on next generation sequencing for DNA methylation. The review also discusses the feasibility of detecting cfDNA methylation and the latest progress.

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DOI: https://doi.org/10.1039/C9AN00935C
Article type: Critical Review
Submitted: 22 May 2019
Accepted: 26 Jul 2019
First published: 22 Aug 2019

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Analyst, 2019,144, 5912-5922

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Analysis of genome-wide in cell free DNA methylation: progress and prospect

Z. Liu, Z. Wang, E. Jia, T. Ouyang, M. Pan, J. Lu, Q. Ge and Y. Bai, Analyst, 2019, 144, 5912 DOI: 10.1039/C9AN00935C

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Analysis of genome-wide in cell free DNA methylation: progress and prospect

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Analysis of genome-wide in cell free DNA methylation: progress and prospect

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