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Dual-entropy-driven catalytic amplification reaction for ultra-sensitive and visible detection of Hg2+ in water based on thymine–Hg2+–thymine coordination chemistry

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Abstract

An ultra-sensitive and visible Hg2+ detection strategy was established. It was based on T–Hg2+–T coordination chemistry and a dual-entropy-driven catalytic reaction (EDCR). The dual EDCR was initiated by T–Hg2+–T coordination chemistry, resulting in the release of a G-rich sequence to form a hemin/G-quadruplex-HRP-mimicking DNAzyme, and then catalyzing 3,3′,5,5′-tetramethylbenzidine (TMB) into TMB+, with a color change from colorless to blue. This method showed great sensitivity and excellent selectivity, and the limit of detection reached 0.6 pM. The feasibility of this method was demonstrated by real water samples. Moreover, the visible color change provided the possibility of ultra-sensitive detection of Hg2+ by the naked eye.

Graphical abstract: Dual-entropy-driven catalytic amplification reaction for ultra-sensitive and visible detection of Hg2+ in water based on thymine–Hg2+–thymine coordination chemistry

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Publication details

The article was received on 14 May 2019, accepted on 12 Jul 2019 and first published on 12 Jul 2019


Article type: Paper
DOI: 10.1039/C9AN00882A
Analyst, 2019, Advance Article

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    Dual-entropy-driven catalytic amplification reaction for ultra-sensitive and visible detection of Hg2+ in water based on thymine–Hg2+–thymine coordination chemistry

    Z. Xiong, Q. Liu, W. Yun, Y. Hu, X. Wang and L. Yang, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN00882A

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