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Issue 17, 2019
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Novel fluorescent probe with a bridged Si–O–Si bond for the reversible detection of hypochlorous acid and biothiol amino acids in live cells and zebrafish

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Abstract

Herein, we report the design of a novel fluorescent probe consisting of a naphthalimide fluorophore and a silicone small molecule for the reversible detection of hypochlorous acid and biothiol amino acids. The response mechanism of BSi-1 is based on the concept of the S-based oxidation/reduction. The probe was found to be suitable for imaging HOCl in HeLa, RAW 264.7 cells and zebrafish, demonstrating its utility in biological applications.

Graphical abstract: Novel fluorescent probe with a bridged Si–O–Si bond for the reversible detection of hypochlorous acid and biothiol amino acids in live cells and zebrafish

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Publication details

The article was received on 09 May 2019, accepted on 01 Jul 2019 and first published on 04 Jul 2019


Article type: Communication
DOI: 10.1039/C9AN00844F
Analyst, 2019,144, 5075-5080

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    Novel fluorescent probe with a bridged Si–O–Si bond for the reversible detection of hypochlorous acid and biothiol amino acids in live cells and zebrafish

    Y. Zhang, Y. Zuo, T. Yang, Z. Gou, X. Wang and W. Lin, Analyst, 2019, 144, 5075
    DOI: 10.1039/C9AN00844F

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