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Vertical Flow Assays Based on Core-Shell SERS Nanotags for Multiplex Prostate Cancer Biomarkers Detection

Abstract

Rapid, simultaneous, and sensitive quantification of multiplex prostate biomarkers plays an important role in early diagnosis, especially for obese men and patients. Herein, a surface-enhanced Raman scattering (SERS)-based vertical flow assay (VFA) is presented for simultaneous detection of multiplex prostate cancer biomarkers, such as prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) on a single test spot. In practice, Raman dyes (RDs) encoded core-shell SERS nanotags instead of conventional gold colloids used in the colorimetric assay are employed in the sensing membrane of SERS based VFA for multiplex proteins detection. Because of the enhanced Raman signal of the core-shell nanostructure and the high surface area to volume ratio (SVR) of the porous sensing membrane, this proposed biosensor shows wide linear dynamic range (LDR) with detection limits of 0.37, 0.43, and 0.26 pg mL-1 for PSA, CEA, and AFP, respectively, suggesting that this approach can be a good candidate in point of care testing (POCT) for rapid and sensitive biomarkers detection and has a prosperous potential in multiplex analysis and cancer diagnosis.

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Supplementary files

Publication details

The article was received on 22 Apr 2019, accepted on 10 May 2019 and first published on 13 May 2019


Article type: Paper
DOI: 10.1039/C9AN00733D
Analyst, 2019, Accepted Manuscript

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    Vertical Flow Assays Based on Core-Shell SERS Nanotags for Multiplex Prostate Cancer Biomarkers Detection

    R. Chen, B. Liu, H. Ni, N. Chang, C. Luan, Q. Ge, J. Dong and X. Zhao, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C9AN00733D

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