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Dual functional turn-on non-toxic chemosensor for highly selective and sensitive visual detection of Mg2+ and Zn2+: solvent-controlled recognition effect and bio-imaging application

Abstract

A new dual functional turn-on chemosensor, (2-hydroxy-5-methyl-1,3-phenylene)bis(methanylylidene)bis(isoquinoline-1-carbohydrazide) (HL), has been developed, which could highly selectively discriminate Mg2+ and Zn2+ in different solvent systems. The chemosensor HL exhibits rapid visual turn-on fluorescent enhancing recognition toward Mg2+/Zn2+, which are not interfered by other cations, especially for respective congeners Ca2+/Cd2+. The remarkable fluorescent enhancement (71-fold or 11-fold) were observed after adding Mg2+ in acetonitrile or Zn2+ in DMF-H2O solvent systems. Additionally such a solvent medium-controlled platform could achieve quantitative determination of Mg2+ and Zn2+ quantitation with low detection limits of 2.97 × 10–8 M and 3.07 × 10–7 M, respectively. Further the turn-on fluorescent sensing mechanism is also investigated by 1H NMR spectra, FT-IR and ESI-MS spectra. Density functional theory (DFT) calculations derive optimized geometries of HL and its complexes. Notably, non-toxic HL also can be successfully applied as a visual probe for practical determination of Mg2+/Zn2+ in MCF-7 cells, Zebrafish larvae, syrup and water samples, which might provide extensive application in biological and medicine field.

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Publication details

The article was received on 31 Mar 2019, accepted on 05 May 2019 and first published on 07 May 2019


Article type: Paper
DOI: 10.1039/C9AN00583H
Analyst, 2019, Accepted Manuscript

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    Dual functional turn-on non-toxic chemosensor for highly selective and sensitive visual detection of Mg2+ and Zn2+: solvent-controlled recognition effect and bio-imaging application

    Y. Wang, Z. Wang, X. Song, Q. Chen, H. Tian, C. Xie, Q. Li and J. Xu, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C9AN00583H

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