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Issue 12, 2019
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Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

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Abstract

Monoamine oxidase (MAO) is a membrane-bound mitochondrial enzyme that plays an important role by catalyzing oxidative deamination to maintain the homeostasis of neurotransmitters and other biogenic amines in living systems. MAO activity is critical for the brain and central nervous system. Its dysfunction is closely related with many neurological and psychiatric disorders. Fluorescent probes provide a useful approach to accurately detect MAO activity and assist to better elucidate their biological functions. Herein, in this Minireview, we summarize the recent advances in reaction based MAO type fluorescent probes and their imaging applications in living systems.

Graphical abstract: Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

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Publication details

The article was received on 03 Mar 2019, accepted on 24 Apr 2019 and first published on 24 Apr 2019


Article type: Minireview
DOI: 10.1039/C9AN00409B
Analyst, 2019,144, 3703-3709

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    Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

    J. Huang, D. Hong, W. Lang, J. Liu, J. Dong, C. Yuan, J. Luo, J. Ge and Q. Zhu, Analyst, 2019, 144, 3703
    DOI: 10.1039/C9AN00409B

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