Jump to main content
Jump to site search


Enhancing the colorimetric detection of H2O2 and ascorbic acid on polypyrrole coated fluconazole-functionalized POMOFs

Author affiliations

Abstract

A new fluconazole-functionalized polyoxometalate-based metal–organic framework (POMOF) [Ag3(FKZ)2(H2O)2][H3SiW12O40] (AgFKZSiW12) was successfully constructed, and its polypyrrole (PPy) coated composite AgFKZSiW12@PPy was also obtained via a facile ‘in situ’ oxidation polymerization process. The peroxidase-like activity evaluation indicates that the maximized synergistic effect from the integration of PPy, SiW12 clusters, HFKZ drug molecules, and Ag ions deeply enhanced the overall performance. More importantly, AgFKZSiW12@PPy exhibits the fastest response time (30 s) among all the reported peroxidase mimics to date, including the pristine AgFKZSiW12 (2 min). Moreover, the AgFKZSiW12@PPy-based colorimetric biosensing platform towards H2O2 and ascorbic acid (AA) exhibits limits of detection (LOD) as low as 0.12 μM and 2.7 μM, respectively. This work reveals a promising prospect in medical diagnosis and biotechnology for colorimetric biosensor fabrication with high performance through the introduction of PPy.

Graphical abstract: Enhancing the colorimetric detection of H2O2 and ascorbic acid on polypyrrole coated fluconazole-functionalized POMOFs

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jan 2019, accepted on 25 Mar 2019 and first published on 28 Mar 2019


Article type: Paper
DOI: 10.1039/C9AN00163H
Citation: Analyst, 2019, Advance Article

  •   Request permissions

    Enhancing the colorimetric detection of H2O2 and ascorbic acid on polypyrrole coated fluconazole-functionalized POMOFs

    X. Li, L. Sun, X. Yang, K. Zhou, G. Zhang, Z. Tong, C. Wang and J. Sha, Analyst, 2019, Advance Article , DOI: 10.1039/C9AN00163H

Search articles by author

Spotlight

Advertisements