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Multifunctional titanium phosphate nanoparticles for site-specific drug delivery and real-time therapeutic efficacy evaluation

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Abstract

Receptor-targeted delivery systems have been proposed as means of concentrating therapeutic agents to improve therapeutic effects on disease sites and reduce side effects on normal issues. Herein, we synthesized biocompatible folic acid (FA)-functionalized DHE-modified TiP (TiP-PAH-DHE-FA) nanoparticles as a drug delivery system that possessed high drug loading capability and enhanced folate-receptor-mediated cellular uptake. Moreover, it also allowed drug effect evaluation based on the real-time monitoring of the fluorescence intensity of HE molecules that are triggered by intercellular ROS. This acquired drug delivery system provided a novel platform to integrate efficient cell-specific drug delivery with real-time monitoring of therapeutic efficacy.

Graphical abstract: Multifunctional titanium phosphate nanoparticles for site-specific drug delivery and real-time therapeutic efficacy evaluation

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Publication details

The article was received on 18 Dec 2018, accepted on 11 Mar 2019 and first published on 13 Mar 2019


Article type: Paper
DOI: 10.1039/C8AN02450B
Citation: Analyst, 2019, Advance Article

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    Multifunctional titanium phosphate nanoparticles for site-specific drug delivery and real-time therapeutic efficacy evaluation

    F. Cheng, P. Sun, W. Xiong, Y. Zhang, Q. Zhang, W. Yao, Y. Cao and L. Zhang, Analyst, 2019, Advance Article , DOI: 10.1039/C8AN02450B

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