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Peroxydisulfate/oxygen system-based electrochemiluminescent immunosensing of Hg2+ using Pt/Pd nanodendrites-thiosemicarbazide/norfloxacin as a signal enhancer

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Abstract

Herein, we describe a competitive-type electrochemiluminescence (ECL) strategy for Hg2+ determination based on the peroxydisulfate/oxygen (S2O82−/O2) system that uses Pt/Pd nanodendrites (Pt/Pd NDs)-thiosemicarbazide/norfloxacin (TN)-covered gold nanoparticles (Pt/Pd-TNG50) as a signal enhancer. The Pt/Pd NDs, a dense array of Pt branches on a Pd core, possessed excellent catalytic properties to enhance ECL intensity by accelerating electron transfer. In addition, the binary intramolecular synergy of TN, which had cooperative interactions of powerful π–π stacking with a larger conjugated surface, could extremely enhance the ECL signal of the S2O82−/O2 system. Furthermore, we designed a competitive immunoassay method using a structured sensor where a monoclonal antibody (mAb) against Hg2+ exhibited high specificity and recognition of Hg2+, which greatly improved the specificity and sensitivity of the immunosensor. As a result, the proposed immunosensor gave Hg2+ detection with a low detection limit (16 pg mL−1) and displayed high sensitivity and stability. Importantly, this work not only, for the first time to our knowledge, utilized Pt/Pd NDs as promising ECL emitters for bioprobe construction but also opened an efficient way for the detection of Hg2+ in environmental monitoring.

Graphical abstract: Peroxydisulfate/oxygen system-based electrochemiluminescent immunosensing of Hg2+ using Pt/Pd nanodendrites-thiosemicarbazide/norfloxacin as a signal enhancer

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Publication details

The article was received on 10 Dec 2018, accepted on 19 Dec 2018 and first published on 21 Dec 2018


Article type: Paper
DOI: 10.1039/C8AN02386G
Citation: Analyst, 2019, Advance Article

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    Peroxydisulfate/oxygen system-based electrochemiluminescent immunosensing of Hg2+ using Pt/Pd nanodendrites-thiosemicarbazide/norfloxacin as a signal enhancer

    C. Wang, Q. Tang, K. Zhao, A. Deng and J. Li, Analyst, 2019, Advance Article , DOI: 10.1039/C8AN02386G

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