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A novel fluorescent sensing platform based Metal-Polydopamine Frameworks for dual Detection of Kanamycin and Oxytetracycline

Abstract

In this report, we have presented for the first time about dual detection of kanamycin (KMY) and oxyteracycline (OTC) using metal polydopamine frameworks (MPDA). This sensing system represents the metal polydopamine frameworks (MPDA) which act as a fluorescent quencher between the interaction the MPDA and dye labeled DNA molecules. The metal polydopamine frameworks exhibited an excellent fluorescent quenching behaviour and good analytical response towards the detection of biomolecules for KMY and OTC. The accumulation of kanamycin and oxyteracycline into the sensing system was recovered and monitored the fluorescent intensity was changes at 525 and 583 nm. Under the optimal conditions, the proposed sensing system remarkably achieved for the highly sensitivity and selectivity detection of KMY and OTC with limit of detection of 304 pM and 481 pM respectively. The selectivity of the developed sensor was explored in the presence of competitive biomolecules. Moreover this sensing system demonstrates the great potential and versatile to rapid detection. In addition, this biosensor has been successfully evaluated for the dual detection of KMY and OTC in different real samples.

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Publication details

The article was received on 05 Dec 2018, accepted on 05 Feb 2019 and first published on 06 Feb 2019


Article type: Paper
DOI: 10.1039/C8AN02363H
Citation: Analyst, 2019, Accepted Manuscript

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    A novel fluorescent sensing platform based Metal-Polydopamine Frameworks for dual Detection of Kanamycin and Oxytetracycline

    R. Ayyanu and P. Perumal, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C8AN02363H

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