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Effective imprinting of an anticancer drug, 6-thioguanine, via mussel inspired self-polymerization of dopamine over reduced graphene oxide

Abstract

Apart from being a vital catecholamine molecule responsible for the proper functioning of central nervous system (CNS), hormonal and renal systems, dopamine (DA) has also been increasingly employed as a functional monomer in the fabrication of surface molecular imprinting polymer (MIP) of valuable analytes. Herein, we demonstrate the effective imprinting of 6-thioguanine (6-TG), an anticancer drug, via mussel-inspired self-polymerization of dopamine conducted in weakly alkaline solution over reduced graphene oxide (rGO). The polymerization of 6-TG resulted into a thin polydopamine (PDA) film of 8.4 nm thickness with complementary cavities for 6-TG binding after the convenient removal of 6-TG molecules. The electrochemical investigation of MIP electrode exhibited excellent electrocatalytic activity toward 6-TG with significant decrease in over-potential as compared to bare glassy carbon electrode (GCE) which can be attributed to graphene's distinct physical and chemical features such as subtle electronic characteristics, attractive π–π interaction, and strong adsorptive capability of MIP film. This electrochemical sensor displays high selectivity owing to specific imprinted cavities for adrenaline and worked well over a wide linear concentration range of adrenaline between 0.0015-50 µM with a detection limit (LOD) of 0.25 nM and good reproducibility and stability. Our system depicts excellent recoveries from 97.0% to 100.6% for two different samples of urine and thioguanine drugs. These results show the great potential of our system with multiple advantages including convenient fabrication and optimization, high sensitivity and selectivity, high reproducibility and stability, and cost effectiveness.

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Publication details

The article was received on 04 Dec 2018, accepted on 03 Feb 2019 and first published on 04 Feb 2019


Article type: Paper
DOI: 10.1039/C8AN02348D
Citation: Analyst, 2019, Accepted Manuscript

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    Effective imprinting of an anticancer drug, 6-thioguanine, via mussel inspired self-polymerization of dopamine over reduced graphene oxide

    S. A. Zaidi, Analyst, 2019, Accepted Manuscript , DOI: 10.1039/C8AN02348D

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