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Detection of sulfadimethoxine using optical images of liquid crystals

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Abstract

A label-free method for sulfadimethoxine (SDM) detection using an aptamer-based liquid crystal biosensor is developed. The sensor probe is fabricated by immobilizing amine-functionalized aptamers onto the glass slide decorating mixed self-assembled layers of triethoxysilylbutyraldehyde (TEA) and N,N-dimethyl-n-octadecyl-3-aminopropyltrimethoxysilylchloride (DMOAP). Liquid crystals (LCs) are supported on the surface and serve as response elements, which assume the homeotropic alignment and cause a dark optical appearance under crossed polarizers. In the presence of SDM, the formation of SDM–aptamer compounds induces a notable change in the topographical structure of the surface, which disturbs the original homeotropic orientation of LCs and results in a bright optical appearance. A detection limit of 10 μg L−1 is obtained, which is far lower than the maximum residue limit (100 μg L−1 in China). This facile method shows good specificity for SDM detection and may have great potential for detecting other small molecules.

Graphical abstract: Detection of sulfadimethoxine using optical images of liquid crystals

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Publication details

The article was received on 25 Oct 2018, accepted on 28 Dec 2018 and first published on 03 Jan 2019


Article type: Paper
DOI: 10.1039/C8AN02049C
Citation: Analyst, 2019, Advance Article

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    Detection of sulfadimethoxine using optical images of liquid crystals

    J. Du, Q. Jiang, X. Lu, L. Chen, Y. Zhang and X. Xiong, Analyst, 2019, Advance Article , DOI: 10.1039/C8AN02049C

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