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Visual detection of cancer cells by using in situ grown functional Cu2−xSe/reduced graphene oxide hybrids acting as an efficient nanozyme

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Abstract

A simple protocol for in situ growth of Cu2−xSe nanoparticles on graphene oxide hybrids (Cu2−xSe/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2−xSe/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2−xSe/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. The results showed that the Cu2−xSe/rGO hybrids could be the promising nanozyme mimetics for potential applications in bioanalytical fields.

Graphical abstract: Visual detection of cancer cells by using in situ grown functional Cu2−xSe/reduced graphene oxide hybrids acting as an efficient nanozyme

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Publication details

The article was received on 25 Sep 2018, accepted on 06 Nov 2018 and first published on 07 Nov 2018


Article type: Paper
DOI: 10.1039/C8AN01849A
Citation: Analyst, 2019, Advance Article
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    Visual detection of cancer cells by using in situ grown functional Cu2−xSe/reduced graphene oxide hybrids acting as an efficient nanozyme

    Q. J. Guo, Z. Y. Pan, C. Men, W. Y. Lv, H. Y. Zou and C. Z. Huang, Analyst, 2019, Advance Article , DOI: 10.1039/C8AN01849A

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