Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 4, 2019
Previous Article Next Article

Direct sampling mass spectrometry for clinical analysis

Author affiliations


Direct sampling mass spectrometry (MS) has been advancing aggressively, showing immense potential in translating MS into the clinical field. Unlike traditional MS analysis involving extensive sample preparation and chromatographic separation, quick and simple procedures with minimal sample pretreatment or purification became available with direct sampling. An overview of the development in this field is provided, including some representative ambient ionization and fast extraction methods. Quantitative applications of these methods are emphasized and their efficacy are highlighted from a clinical aspect; non-quantitative applications in clinical analysis are also discussed. This review also discusses the integration of direct sampling MS with miniature mass spectrometers and its future outlook as an emerging clinical tool for point-of-care analysis.

Graphical abstract: Direct sampling mass spectrometry for clinical analysis

Back to tab navigation

Publication details

The article was received on 05 Sep 2018, accepted on 30 Nov 2018 and first published on 03 Dec 2018

Article type: Critical Review
DOI: 10.1039/C8AN01722K
Analyst, 2019,144, 1034-1051

  •   Request permissions

    Direct sampling mass spectrometry for clinical analysis

    F. Pu, S. Chiang, W. Zhang and Z. Ouyang, Analyst, 2019, 144, 1034
    DOI: 10.1039/C8AN01722K

Search articles by author