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Microfluidic bioanalytical flow cells for biofilm studies: a review

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Abstract

Bacterial biofilms are among the oldest and most prevalent multicellular life forms on Earth and are increasingly relevant in research areas related to industrial fouling, medicine and biotechnology. The main hurdles to obtaining definitive experimental results include time-varying biofilm properties, structural and chemical heterogeneity, and especially their strong sensitivity to environmental cues. Therefore, in addition to judicious choice of measurement tools, a well-designed biofilm study requires strict control over experimental conditions, more so than most chemical studies. Due to excellent control over a host of physiochemical parameters, microfluidic flow cells have become indispensable in microbiological studies. Not surprisingly, the number of lab-on-chip studies focusing on biofilms and other microbiological systems with expanded analytical capabilities has expanded rapidly in the past decade. In this paper, we comprehensively review the current state of microfluidic bioanalytical research applied to bacterial biofilms and offer a perspective on new approaches that are expected to drive continued advances in this field.

Graphical abstract: Microfluidic bioanalytical flow cells for biofilm studies: a review

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Publication details

The article was received on 07 Aug 2018, accepted on 16 Oct 2018 and first published on 17 Oct 2018


Article type: Critical Review
DOI: 10.1039/C8AN01526K
Citation: Analyst, 2019, Advance Article
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    Microfluidic bioanalytical flow cells for biofilm studies: a review

    M. Pousti, M. P. Zarabadi, M. Abbaszadeh Amirdehi, F. Paquet-Mercier and J. Greener, Analyst, 2019, Advance Article , DOI: 10.1039/C8AN01526K

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