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Issue 5, 2019
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Click chemistry at the microscale

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Click chemistry has attracted tremendous attention for the fabrication of novel microscale systems based on its high reaction efficiency, satisfactory versatility and simple processing. Meanwhile, microscale systems also provide desirable analytical platforms for click reaction study. Herein, we review the employment of click reactions for developing state-of-the-art microchip-based and capillary-based systems. The advantages of innovative off-stoichiometry thiol–ene (OSTE)-microchips, bio-functionalized microchips and monolithic microsystems for chemical and biological assays are highlighted. Moreover, the potential of microscale systems applied for click reaction investigation is indicated as well. This article presents an overview of the recent developments in the combination of microscale systems and click chemistry.

Graphical abstract: Click chemistry at the microscale

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Publication details

The article was received on 04 Aug 2018, accepted on 01 Dec 2018 and first published on 12 Dec 2018

Article type: Critical Review
DOI: 10.1039/C8AN01497C
Analyst, 2019,144, 1492-1512

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    Click chemistry at the microscale

    T. Hong, W. Liu, M. Li and C. Chen, Analyst, 2019, 144, 1492
    DOI: 10.1039/C8AN01497C

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