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Issue 5, 2019
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Click chemistry at the microscale

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Click chemistry has attracted tremendous attention for the fabrication of novel microscale systems based on its high reaction efficiency, satisfactory versatility and simple processing. Meanwhile, microscale systems also provide desirable analytical platforms for click reaction study. Herein, we review the employment of click reactions for developing state-of-the-art microchip-based and capillary-based systems. The advantages of innovative off-stoichiometry thiol–ene (OSTE)-microchips, bio-functionalized microchips and monolithic microsystems for chemical and biological assays are highlighted. Moreover, the potential of microscale systems applied for click reaction investigation is indicated as well. This article presents an overview of the recent developments in the combination of microscale systems and click chemistry.

Graphical abstract: Click chemistry at the microscale

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Article information

04 Aug 2018
01 Dec 2018
First published
12 Dec 2018

Analyst, 2019,144, 1492-1512
Article type
Critical Review

Click chemistry at the microscale

T. Hong, W. Liu, M. Li and C. Chen, Analyst, 2019, 144, 1492
DOI: 10.1039/C8AN01497C

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