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Issue 3, 2019
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Single-cell assay on microfluidic devices

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Abstract

Advances in microfluidic techniques have prompted researchers to study the inherent heterogeneity of single cells in cell populations. This would be helpful in the identification of major diseases and the design of personalized medicine. Different microfluidic approaches provide a variety of functions in the process of single-cell analysis. In this review, we take a broad overview of various microfluidic-based approaches for single-cell isolation, single-cell lysis, and single-cell analysis. Up-to-date flagship techniques and the pros and cons of these methods are discussed in detail.

Graphical abstract: Single-cell assay on microfluidic devices

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Article information


Submitted
12 Jun 2018
Accepted
22 Aug 2018
First published
22 Aug 2018

Analyst, 2019,144, 808-823
Article type
Critical Review

Single-cell assay on microfluidic devices

Q. Huang, S. Mao, M. Khan and J. Lin, Analyst, 2019, 144, 808
DOI: 10.1039/C8AN01079J

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