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Issue 4, 2019
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Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use

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Abstract

Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future.

Graphical abstract: Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use

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Publication details

The article was received on 07 Jan 2019, accepted on 26 Apr 2019 and first published on 29 Apr 2019


Article type: Review Article
DOI: 10.1039/C9TX00002J
Toxicol. Res., 2019,8, 489-498
  • Open access: Creative Commons BY-NC license
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    Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use

    D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489
    DOI: 10.1039/C9TX00002J

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