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Issue 39, 2019
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Styrene maleic acid copolymer induces pores in biomembranes

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Abstract

We investigated the interactions between styrene–maleic acid (SMA) copolymers and phospholipid bilayers, using confocal microscopy and surface acoustic wave resonance (SAR) sensing. For the first time we experimentally observed and followed pore formation by SMA copolymers in intact supported bilayers and unilamellar vesicles, showing that fluorescein, a water-soluble organic compound with a mean diameter of 6.9 Å, can traverse the membrane. Our findings are in agreement with recent theoretical predictions, which suggested that SMA copolymers may insert along the plane of the bilayer to form stable toroidal pores.

Graphical abstract: Styrene maleic acid copolymer induces pores in biomembranes

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Publication details

The article was received on 11 Jul 2019, accepted on 03 Sep 2019 and first published on 20 Sep 2019


Article type: Paper
DOI: 10.1039/C9SM01407A
Soft Matter, 2019,15, 7934-7944
  • Open access: Creative Commons BY-NC license
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    Styrene maleic acid copolymer induces pores in biomembranes

    M. Orwick Rydmark, M. K. Christensen, E. S. Köksal, I. Kantarci, K. Kustanovich, V. Yantchev, A. Jesorka and I. Gözen, Soft Matter, 2019, 15, 7934
    DOI: 10.1039/C9SM01407A

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